In this ground-breaking tour of the human mind, a world-renowned psychiatrist and neuroscientist explores the origins of human emotion through the stories of his patients. Why do we feel what we feel? How do we define ‘sanity’? Can a lost mind be found again? Since the dawn of humankind, mental illness has been one of our greatest causes of suffering as a species. But for the majority of our history, its causes have remained a mystery. Now, science has reached a tipping point. In ‘Connections’, Professor Karl Deisseroth shares his breakthrough discovery, Optogenetics, a biological technique that allows us to decipher the brain’s inner workings using light.

ISBN: 9780241381861 Author: Deisseroth, Karl Publisher: Viking Publication Date: 17th June 2021 Imprint: Viking Cover: Hardback Dewey: 152.4 (edition:23) Pages: 231 Language: English Readership: General - Trade / Code: K Category: Subjects: , , , , ,

In this riveting journey through the hidden realms of the human mind, a world-renowned psychiatrist and neuroscientist explores the origins of human emotion, and examines what mental illnesses reveal about all of us – how the broken can illuminate the unbroken.

‘Remarkable … he has reimagined and redefined what literary non-fiction can be … poetic, mind-stretching, and through it all, deeply human’ Daniel Levitin

‘Revelatory … it recalls the case histories of Oliver Sacks, at times the sweep of Yuval Harari’s Sapiens. He writes with an evident love of words – but also, with a lucid line of scientific enquiry’ Guardian

Why do we feel what we feel?

Mental illness is one of the greatest causes of human suffering, but the reasons we bear this burden, and the nature of these diseases, have remained mysterious. Now, our understanding has reached a tipping point. In Connections, Professor Karl Deisseroth intertwines gripping case studies from his experience as an emergency psychiatry physician, with breakthrough scientific discoveries from astounding new technology (including optogenetics, which he developed to allow turning specific brain cells on or off, with light).

By linking insights from this technology to deeply moving stories of his patients and to our shared evolutionary history, Deisseroth tells a larger story about the origins of human emotion. A young woman with an eating disorder reveals how the mind can rebel against the brain’s most primitive drives of hunger and thirst; an older man, smothered into silence by dementia, shows how humans evolved to feel joy and its absence; and a lonely Uyghur woman far from her homeland teaches both the importance – and challenges – of deep social bonds.

Addressing some of the most timeless questions about the human condition while illuminating the roots of misunderstood disorders such as depression, psychosis, schizophrenia and sociopathy, Connections transforms the way we understand the brain, and our selves.

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